Lecture

Lecture - 20 Nucleic Acids 1

This module introduces Nucleic Acids I, focusing on the structures and functions of DNA and RNA. We'll explore:

  • Basic structure of nucleotides
  • DNA double helix and RNA single-stranded structure
  • Functions of DNA in heredity and protein synthesis
  • Role of RNA in various biological processes

By the end of this module, students will understand the fundamental roles of nucleic acids in living organisms.


Course Lectures
  • Lecture - 1 Amino Acids I
    Prof. S. Dasgupta

    This module delves into the fundamental building blocks of proteins, amino acids. Students will explore the structure, properties, and functions of amino acids. The lecture will cover the classification of amino acids based on their side chains, the role of amino acids in protein synthesis, and their importance in metabolic pathways. Understanding amino acids is crucial for grasping more complex biochemical processes. Additionally, students will learn about the significance of amino acids in nutrition and health.

    • Introduction to amino acids
    • Structure and classification
    • Role in protein synthesis
    • Metabolic pathways
    • Nutritional significance
  • Lecture - 2 Amino Acids II
    Prof. S. Dasgupta

    This module continues the exploration of amino acids, focusing on their chemical properties and how these properties influence protein function and interactions. Students will learn about amino acid sequencing and its importance in determining protein structure. The lecture will also address various methods used to analyze amino acid composition in proteins. Emphasis will be placed on understanding how amino acids contribute to the dynamic nature of proteins in biological systems.

    • Chemical properties of amino acids
    • Amino acid sequencing
    • Methods of analysis
    • Protein interactions
    • Biological significance
  • This module introduces students to the intricate world of protein structure. The lecture covers the primary, secondary, tertiary, and quaternary levels of protein structure. Students will learn how these structures are formed and stabilized, and their significance in determining protein function. The lecture will also highlight different techniques used to study protein structures, such as X-ray crystallography and NMR spectroscopy.

    • Levels of protein structure
    • Formation and stabilization
    • Functional significance
    • Techniques for studying proteins
    • Applications in research
  • This module delves deeper into protein structures, with a focus on the secondary and tertiary structures. Students will explore the types of bonds and interactions that stabilize these structures and how alterations in structure can affect protein function. The lecture will also cover the concept of protein folding and misfolding, which is critical in understanding many diseases. Advanced analytical methods for studying these structures will also be discussed.

    • Secondary and tertiary structures
    • Bonds and interactions
    • Protein folding and misfolding
    • Impact on function
    • Analytical methods
  • This module explores the complex quaternary structures of proteins. Students will learn how multiple polypeptide chains interact to form functional protein complexes. The lecture will discuss examples of quaternary structures, such as hemoglobin, and how these structures are crucial for biological function. Additionally, students will study how changes in quaternary structure can lead to various diseases and disorders.

    • Quaternary protein structures
    • Polypeptide interactions
    • Functional protein complexes
    • Examples: Hemoglobin
    • Role in diseases
  • This module completes the comprehensive overview of protein structures by focusing on advanced topics in protein structure analysis. Students will explore the dynamic nature of protein structures and the techniques used to observe these changes. The lecture will also discuss the impact of post-translational modifications on protein function and how these modifications are studied. Emphasis will be on real-world applications and current research trends in protein engineering.

    • Dynamic protein structures
    • Observation techniques
    • Post-translational modifications
    • Impact on function
    • Protein engineering
  • Lecture - 7 Enzymes I
    Prof. S. Dasgupta

    This module introduces the basics of enzyme biology, focusing on enzyme structure, function, and classification. Students will explore the mechanisms by which enzymes catalyze reactions, their role in metabolic pathways, and factors affecting enzyme activity. The lecture will also cover enzyme kinetics, providing a foundation for understanding how enzymes work at a molecular level. Students will learn about the practical applications of enzymes in industry and medicine.

    • Enzyme structure and function
    • Enzyme classification
    • Reaction mechanisms
    • Factors affecting activity
    • Enzyme kinetics
  • Lecture - 8 Enzymes 2
    Prof. S. Dasgupta

    This module delves into the intricate world of enzymes, exploring their role as biological catalysts. Enzymes are pivotal for various biochemical reactions, accelerating processes crucial for life. The module will cover:

    • Enzyme structure and function
    • Factors affecting enzyme activity
    • Enzyme kinetics and regulation
    • Applications of enzymes in biotechnology

    Students will gain an understanding of how enzymes transform substrates into products, the significance of active sites, and the impact of inhibitors and activators on enzyme efficiency.

  • Lecture - 9 Enzymes III
    Prof. S. Dasgupta

    This module continues the exploration of enzymes, focusing on advanced concepts related to enzyme activity and mechanisms. Students will learn about:

    • Enzyme cofactors and coenzymes
    • Allosteric regulation
    • Enzyme inhibition types
    • Real-world applications of enzyme knowledge

    By understanding these concepts, students will be better equipped to analyze enzyme function in various biological contexts, including metabolic pathways and disease states.

  • This module introduces students to enzyme mechanisms, illustrating how enzymes facilitate biochemical reactions. Key topics include:

    • Mechanistic pathways of enzyme action
    • Transition states and activation energy
    • Mechanism-based inhibitors

    Through case studies and examples, students will learn how to analyze enzyme mechanisms, enhancing their understanding of enzyme specificity and efficiency.

  • This module continues the examination of enzyme mechanisms, expanding on previous concepts with a focus on molecular interactions. Students will explore:

    • Detailed mechanisms of key enzymes
    • Biophysical techniques used in enzyme studies
    • Thermodynamics in enzymatic reactions

    Through interactive discussions and practical examples, students will develop the ability to predict enzyme behavior under various conditions.

  • This module centers on myoglobin and hemoglobin, two crucial proteins involved in oxygen transport. Key points of study will include:

    • Structure and function of myoglobin
    • Oxygen binding and release mechanisms
    • Differences between myoglobin and hemoglobin

    Students will explore how these proteins facilitate respiration and their significance in muscle function, highlighting the impact of pH and carbon dioxide on binding.

  • This module covers lipids and membranes, essential components of cellular structure and function. Topics to be discussed include:

    • Types of lipids and their biological roles
    • Cell membrane structure and fluidity
    • Membrane proteins and their functions

    Students will gain insights into how lipids contribute to membrane dynamics and the processes of cell signaling and transport.

  • This module is a continuation of the study of lipids and membranes, delving deeper into their functions and significance. Key topics include:

    • Membrane transport mechanisms
    • Role of cholesterol in membranes
    • Membrane potential and signaling

    Students will explore the complex interactions that govern membrane behavior and the implications for cellular communication and integrity.

  • In this module, we delve into Membrane Transport, exploring how substances move across biological membranes, which is crucial for maintaining cellular homeostasis. Key topics include:

    • Types of transport: passive and active
    • Mechanisms of transport proteins
    • Importance of ion channels and pumps
    • Endocytosis and exocytosis

    Understanding these concepts is vital for grasping how cells interact with their environment and regulate internal conditions.

  • Lecture - 16 Carbohydrates I
    Prof. S. Dasgupta

    This module focuses on Carbohydrates I, the essential biomolecules that serve as energy sources and structural components. We'll cover:

    • Types of carbohydrates: monosaccharides, disaccharides, and polysaccharides
    • Functions of carbohydrates in living organisms
    • Importance of glycosidic bonds
    • Role of carbohydrates in metabolism

    By the end of this module, you will have a foundational understanding of carbohydrates and their significance in biochemistry.

  • Lecture - 17 Carbohydrates II
    Prof. S. Dasgupta

    Continuing from Carbohydrates I, this module, Carbohydrates II, further explores complex carbohydrates and their biological significance. Topics include:

    • Structural polysaccharides like cellulose and chitin
    • Storage polysaccharides: starch and glycogen
    • Carbohydrate metabolism pathways
    • Role of carbohydrates in cellular signaling

    Students will gain a deeper understanding of how these molecules contribute to various biological functions.

  • This module provides an overview of Vitamins and Coenzymes I, focusing on their vital roles in biochemical reactions. Key aspects include:

    • Definition and importance of vitamins
    • Water-soluble vs fat-soluble vitamins
    • Role of coenzymes in enzymatic reactions
    • Deficiency diseases associated with vitamins

    Understanding these concepts is essential for grasping how vitamins and coenzymes influence metabolic processes.

  • In Vitamins and Coenzymes II, we continue examining these essential molecules, focusing on specific vitamins and their biochemical functions. The module will cover:

    • Key vitamins: A, D, E, K, and their roles
    • The impact of vitamins on enzyme activity
    • How coenzymes assist in metabolic pathways
    • Sources of vitamins in the diet

    This comprehensive understanding will highlight the significance of vitamins in maintaining health and supporting metabolic functions.

  • Lecture - 20 Nucleic Acids 1
    Prof. S. Dasgupta

    This module introduces Nucleic Acids I, focusing on the structures and functions of DNA and RNA. We'll explore:

    • Basic structure of nucleotides
    • DNA double helix and RNA single-stranded structure
    • Functions of DNA in heredity and protein synthesis
    • Role of RNA in various biological processes

    By the end of this module, students will understand the fundamental roles of nucleic acids in living organisms.

  • Lecture - 21 Nucleic Acids II
    Prof. S. Dasgupta

    Continuing from Nucleic Acids I, this module, Nucleic Acids II, delves deeper into the roles of nucleic acids in cellular processes. Key topics include:

    • Transcription and translation processes
    • Role of messenger RNA (mRNA) in protein synthesis
    • Regulation of gene expression
    • Importance of RNA in catalysis (ribozymes)

    Students will gain insights into the complex interactions between nucleic acids and cellular mechanisms.

  • Lecture - 22 Nucleic Acids III
    Prof. S. Dasgupta

    This module explores the structure and function of nucleic acids, focusing on DNA and RNA. You will learn about:

    • The chemical composition of nucleotides
    • Base pairing and the double helix structure of DNA
    • The role of RNA in protein synthesis
    • Various types of RNA, including mRNA, tRNA, and rRNA
    • DNA replication and repair mechanisms
    • Gene expression and regulation

    By the end of this module, you will have a solid understanding of how nucleic acids contribute to heredity and cellular function.

  • Lecture - 23 Bioenergetics 1
    Prof. S. Dasgupta

    In this module, we delve into the fundamentals of bioenergetics, examining how energy is produced and utilized in biological systems. Key topics include:

    • Thermodynamics in biological contexts
    • ATP as the energy currency of the cell
    • Energy transformations in metabolic pathways
    • The role of enzymes in energy transfer
    • Oxidative phosphorylation and cellular respiration

    This foundational knowledge will help you understand how energy impacts cellular functions and metabolism.

  • Lecture - 24 Bioenergetics II
    Prof. S. Dasgupta

    This second part of bioenergetics continues to explore energy dynamics, focusing on the biochemical pathways involved in cellular metabolism. Topics include:

    • Detailed analysis of glycolysis and the Krebs cycle
    • Role of electron transport chain
    • Metabolic regulation and its significance
    • Connection between metabolism and energy production

    By the end of this module, you will appreciate how cells harness energy from nutrients for growth and maintenance.

  • Lecture - 25 Metabolism I
    Prof. S. Dasgupta

    This module introduces the concept of metabolism, detailing the biochemical reactions that maintain the living state of cells. You will cover:

    • Overview of catabolism and anabolism
    • Key metabolic pathways and their regulation
    • The significance of metabolic intermediates
    • Energy balance and metabolic flux

    Understanding these concepts will provide a framework for exploring how organisms convert food into energy.

  • Lecture - 26 Metabolism II
    Prof. S. Dasgupta

    This module continues with metabolism, emphasizing advanced metabolic pathways and their integration within the body. Topics include:

    • Detailed study of lipid metabolism
    • Amino acid metabolism and nitrogen balance
    • Integration of carbohydrate metabolism
    • Hormonal regulation of metabolic pathways

    By the end of this module, you will understand how various metabolic processes are coordinated to maintain homeostasis.

  • Lecture - 27 Metabolism III
    Prof. S. Dasgupta

    This final module on metabolism covers the complexities of biochemical processes, focusing on metabolic disorders and their implications. Key aspects include:

    • Overview of metabolic pathways
    • Impact of genetic factors on metabolism
    • Common metabolic disorders and their treatments
    • Future directions in metabolic research

    By completing this module, you will gain insights into how metabolism is pivotal in health and disease.

  • This concluding module provides an overview of the course, summarizing key concepts discussed throughout. It aims to consolidate your understanding of:

    • Major biomolecules, their structures, and functions
    • Metabolic pathways and their regulation
    • The importance of bioenergetics in cellular processes
    • Current research trends in biochemistry

    Students will engage in discussions about the applications of biochemistry in health and industry, reinforcing the relevance of the course content.