Lecture

Mod-01 Lec-12 Lecture-12-Introduction to Biomaterials

This module introduces the assessment techniques for evaluating the biocompatibility of biomaterials. Students will learn about:

  • In vitro and in vivo assessment methods
  • Biochemical assays for biocompatibility testing
  • Regulatory standards for biomaterials

By mastering these techniques, students will be equipped to conduct proper evaluations of biomaterials' safety and efficacy.


Course Lectures
  • Mod-01 Lec-01 Lecture-01-Introduction to Biomaterials
    Dr. Kantesh Balani, Dr. Birkamjit Basu

    This module introduces the fundamental concepts of biomaterials and materials science. It covers the key properties of various material classes that are critical in the development of biomaterials.

    Students will learn about:

    • The definition and importance of biomaterials
    • Basic principles of materials science
    • Salient properties that distinguish biomaterials from other materials

    Understanding these concepts will provide a strong foundation for exploring the advanced topics in biomaterials, such as biocompatibility and material selection for specific biomedical applications.

  • Mod-01 Lec-02 - Lecture-02-Introduction to Biomaterials
    Dr. Kantesh Balani, Dr. Birkamjit Basu

    This module delves into the property requirements of biomaterials and the concept of biocompatibility. Understanding these factors is crucial for the safe and effective use of materials in biological systems.

    The topics covered include:

    • Essential properties required for different types of biomaterials
    • Definition and significance of biocompatibility
    • Factors influencing the biocompatibility of materials
    • Applications of biomaterials in medical devices and implants

    Students will gain insights into the challenges faced in ensuring that biomaterials interact positively with biological tissues.

  • Mod-01 Lec-03 Lecture-03-Introduction to Biomaterials
    Dr. Kantesh Balani, Dr. Birkamjit Basu

    This module focuses on the structure and properties of biological cells and tissues. It examines the intricate relationship between biomaterials and biological systems.

    Key areas of study include:

    • Overview of cell structures and functions
    • Types of tissues and their properties
    • Interactions between cells and materials
    • Role of biomaterials in tissue engineering

    Understanding these components is vital for designing biomaterials that can effectively integrate with biological systems.

  • Mod-01 Lec-04 Lecture-04-Introduction to Biomaterials
    Dr. Kantesh Balani, Dr. Birkamjit Basu

    This module explores cell-material interactions and the foreign body response. Understanding these interactions is essential for the successful application of biomaterials in clinical settings.

    Topics discussed include:

    • Mechanisms of cell-material interactions
    • Foreign body response to implanted materials
    • Influence of surface properties on cellular responses
    • Strategies to enhance biocompatibility through design

    Students will learn how to evaluate and improve the performance of biomaterials in biological environments.

  • Mod-01 Lec-05 Lecture-05-Introduction to Biomaterials
    Dr. Kantesh Balani, Dr. Birkamjit Basu

    This module covers the assessment of the biocompatibility of biomaterials through various in vitro biochemical assays. Students will learn the importance of these assessments in the biomaterials field.

    Key assays include:

    • Cellular adhesion assays to evaluate material surface properties
    • Cellular viability assays using the MTT method
    • Osteogenic differentiation assessment using ALP assay
    • Biomineralization evaluation with Osteocalcin assay

    These techniques are crucial for determining how well biomaterials integrate and function within biological systems.

  • Mod-01 Lec-06 Lecture-06-Introduction to Biomaterials
    Dr. Kantesh Balani, Dr. Birkamjit Basu

    This module discusses in vivo testing and histocompatibility assessment of biomaterials, exploring how these evaluations are performed to ensure safety and efficacy.

    Topics covered include:

    • Methods for in vivo testing of biomaterials
    • Histocompatibility assessment techniques
    • Factors affecting biocompatibility in live systems
    • Case studies of successful and unsuccessful biomaterial applications

    Students will understand the importance of thorough testing and assessment in the development of safe biomaterials for clinical use.

  • Mod-01 Lec-07 Lecture-07-Introduction to Biomaterials
    Dr. Kantesh Balani, Dr. Birkamjit Basu

    This module provides an overview of genotoxicity assessment, focusing on the physical damage to DNA by biomaterial eluates. Understanding these effects is vital for ensuring the safety of biomaterials.

    Key areas include:

    • Definition and significance of genotoxicity
    • Methods for assessing DNA damage
    • Impact of biomaterial eluates on cellular DNA
    • Strategies to minimize genotoxic effects in biomaterials

    Students will learn how to evaluate the potential risks associated with biomaterials and their interaction with biological systems.

  • Mod-01 Lec-08 Lecture-08-Introduction to Biomaterials
    Dr. Kantesh Balani, Dr. Birkamjit Basu

    This module provides an overview of the fundamental concepts of materials science, focusing on the properties of various material classes. Students will explore:

    • Definitions and significance of materials science
    • Key properties of metals, ceramics, and polymers
    • Comparison of material classes relevant to biomaterials

    By understanding these basic concepts, students will appreciate how material selection plays a crucial role in biomedical applications.

  • Mod-01 Lec-09 Lecture-09-Introduction to Biomaterials
    Dr. Kantesh Balani, Dr. Birkamjit Basu

    This module delves into the essential property requirements of biomaterials and the concept of biocompatibility. Key topics include:

    • Understanding the need for biocompatibility in material selection
    • Criteria for assessing biomaterials suitability
    • The relationship between material properties and biological responses

    Students will gain insights into how these properties impact the performance of materials in biological environments.

  • Mod-01 Lec-10 Lecture-10-Introduction to Biomaterials
    Dr. Kantesh Balani, Dr. Birkamjit Basu

    This module focuses on the structure and properties of biological cells and tissues, providing a foundation for understanding cell-material interactions. Topics include:

    • Cell structure and functions
    • Types of biological tissues
    • How materials interact with cells

    Students will learn how these interactions influence the design of biomaterials and their applications in medical devices.

  • Mod-01 Lec-11 Lecture-11-Introduction to Biomaterials
    Dr. Kantesh Balani, Dr. Birkamjit Basu

    This module covers the mechanisms of cell-material interactions and the foreign body response. Key areas include:

    • How cells respond to implanted materials
    • The stages of foreign body response
    • Factors affecting cell behavior at the material interface

    Understanding these concepts is critical for developing better biomaterials that minimize adverse responses in vivo.

  • Mod-01 Lec-12 Lecture-12-Introduction to Biomaterials
    Dr. Kantesh Balani, Dr. Birkamjit Basu

    This module introduces the assessment techniques for evaluating the biocompatibility of biomaterials. Students will learn about:

    • In vitro and in vivo assessment methods
    • Biochemical assays for biocompatibility testing
    • Regulatory standards for biomaterials

    By mastering these techniques, students will be equipped to conduct proper evaluations of biomaterials' safety and efficacy.

  • Mod-01 Lec-13 Lecture-13-Introduction to Biomaterials
    Dr. Kantesh Balani, Dr. Birkamjit Basu

    This module presents various in vitro biochemical assays used to assess the biocompatibility of biomaterials. Key assays covered include:

    • Cellular adhesion tests
    • Cellular viability using MTT assay
    • Osteogenic differentiation via ALP assay
    • Biomineralization assessments using Osteocalcin assay

    Students will gain hands-on experience with these assays, reinforcing their understanding of biomaterial evaluation.

  • Mod-01 Lec-14 Lecture-14-Introduction to Biomaterials
    Dr. Kantesh Balani, Dr. Birkamjit Basu

    This module discusses in vivo testing methods and histocompatibility assessment, focusing on the biological response to implanted materials. Topics include:

    • Designing in vivo experiments
    • Histological evaluation techniques
    • Measuring tissue response to biomaterials

    Students will learn to critically assess tissue compatibility and the overall performance of biomaterials in living organisms.

  • Mod-01 Lec-15 Lecture-15-Introduction to Biomaterials
    Dr. Kantesh Balani, Dr. Birkamjit Basu

    This module introduces the fundamental concepts of Materials Science, focusing on the salient properties of various material classes. You will learn about the significance of materials in a biological context, particularly in the development of biomaterials. Key topics include:

    • Defining Materials Science and its relevance to biomaterials
    • Exploration of different classes of materials and their properties
    • Understanding the integration of materials into biological systems

    Through this module, students will gain a foundational understanding essential for further exploration into biomaterials and their applications.

  • Mod-01 Lec-16 Lecture-16- Introduction to Biomaterials
    Dr. Kantesh Balani, Dr. Birkamjit Basu

    This module dives into the property requirements of biomaterials, emphasizing the critical concept of biocompatibility. Key areas of focus include:

    • Understanding the essential properties that biomaterials must possess
    • Conceptualizing biocompatibility and its importance in material selection
    • Exploring the interaction between biomaterials and biological tissues

    Students will learn how these properties affect the performance of biomaterials in medical applications, setting the stage for in-depth analysis in subsequent modules.

  • Mod-01 Lec-17 Lecture-17- Introduction to Biomaterials
    Dr. Kantesh Balani, Dr. Birkamjit Basu

    This module covers the structure and properties of biological cells and tissues, which are fundamental to understanding biomaterials. Major topics include:

    • Cellular structure: components and their functions
    • Types of tissues: characteristics and relevance in biomaterials
    • Interactions between biomaterials and biological cells

    Students will gain insights into how these biological elements influence the design and functionality of biomaterials, which is critical for successful integration in medical applications.

  • Mod-01 Lec-18 Lecture-18-Introduction to Biomaterials
    Dr. Kantesh Balani, Dr. Birkamjit Basu

    This module focuses on cell-material interactions and foreign body responses, which are crucial for assessing biomaterials. Key points of discussion include:

    • Mechanisms of cell-material interactions
    • Understanding foreign body responses to implanted materials
    • Factors influencing biocompatibility through material interactions

    By studying these topics, students will learn how to evaluate the suitability of biomaterials in clinical settings and anticipate potential challenges in their use.

  • Mod-01 Lec-19 Lecture-19- Introduction to Biomaterials
    Dr. Kantesh Balani, Dr. Birkamjit Basu

    This module provides insights into the assessment of biocompatibility of biomaterials. It covers various testing methods, including:

    • In vitro biochemical assays for evaluating cellular responses
    • Methods for assessing cellular adhesion and viability
    • Techniques for osteogenic differentiation and biomineralization

    Students will engage in hands-on learning to understand how these assessments are conducted and their importance in biomaterial development.

  • Mod-01 Lec-20 Lecture-20- Introduction to Biomaterials
    Dr. Kantesh Balani, Dr. Birkamjit Basu

    This module examines in vivo testing and histocompatibility assessment, which are critical for the evaluation of biomaterials in actual biological systems. Topics include:

    • Overview of in vivo testing methodologies
    • Histocompatibility: understanding tissue reactions
    • Evaluation of biomaterial performance in living organisms

    Students will learn how these assessments contribute to the overall understanding of biomaterial effectiveness and safety in medical applications.

  • Mod-01 Lec-21 Lecture-21- Introduction to Biomaterials
    Dr. Kantesh Balani, Dr. Birkamjit Basu

    This module delves into genotoxicity assessment, focusing on the physical damage to DNA caused by biomaterial eluates. Key areas of exploration include:

    • Understanding genotoxicity and its implications for biomaterials
    • Methods for testing DNA damage
    • The role of biomaterial composition in genotoxicity

    Students will learn how to assess the safety of biomaterials concerning their potential genotoxic effects, a vital aspect in the development of safe medical materials.

  • Mod-01 Lec-22 Lecture-22- Introduction to Biomaterials
    Dr. Kantesh Balani, Dr. Birkamjit Basu

    This module provides an introduction to the fundamental concepts of Materials Science, focusing on the salient properties of various material classes. Students will learn about the essential properties that biomaterials must possess for effective application in medical devices and implants. Key topics include:

    • Overview of Materials Science principles
    • Classification of materials based on their properties
    • Significance of biomaterials in healthcare

    By the end of this module, students will have a solid foundational understanding of how material properties influence the design and selection of biomaterials.

  • Mod-01 Lec-23 Lecture-23- Introduction to Biomaterials
    Dr. Kantesh Balani, Dr. Birkamjit Basu

    This module delves into the specific property requirements for biomaterials, emphasizing the concept of biocompatibility. Students will explore:

    • Definition and importance of biocompatibility
    • Key properties that influence biocompatibility
    • Material interactions with biological systems

    By understanding these concepts, students will gain insights into how biomaterials can be designed to minimize adverse biological responses.

  • Mod-01 Lec-24 Lecture-24- Introduction to Biomaterials
    Dr. Kantesh Balani, Dr. Birkamjit Basu

    This module covers the structure and properties of biological cells and tissues, providing students with insights essential for understanding cell-material interactions. Key topics include:

    • Basic cell structure and function
    • Tissue types and their characteristics
    • Importance of cellular architecture in biomaterial design

    Students will learn how these biological factors influence the performance of biomaterials in medical applications.

  • Mod-01 Lec-25 Lecture-25- Introduction to Biomaterials
    Dr. Kantesh Balani, Dr. Birkamjit Basu

    This module focuses on cell-material interactions and the foreign body response, essential for assessing biomaterial efficacy in vivo. Students will investigate:

    • Mechanisms of cell-material interaction
    • Understanding the foreign body response
    • Factors influencing the success of implants

    By the end of this module, students will grasp how these interactions inform the design and selection of biomaterials for clinical use.

  • Mod-01 Lec-26 Lecture-26-Introduction to Biomaterials
    Dr. Kantesh Balani, Dr. Birkamjit Basu

    In this module, students will explore the methodologies for assessing the biocompatibility of biomaterials. Key assessment techniques include:

    • In vitro biochemical assays
    • Cellular adhesion and viability tests
    • Osteogenic differentiation and biomineralization assessments

    Students will engage in practical experiments to understand the implications of biocompatibility in biomaterials' performance.

  • Mod-01 Lec-27 Lecture-27- Introduction to Biomaterials
    Dr. Kantesh Balani, Dr. Birkamjit Basu

    This module introduces students to in vivo testing methods and histocompatibility assessment for biomaterials. They will cover:

    • Principles of in vivo testing
    • Histocompatibility evaluation methods
    • Importance of genotoxicity assessment in biomaterials

    By understanding these methodologies, students will learn how to evaluate the safety and efficacy of biomaterials before clinical application.

  • Mod-01 Lec-28 Lecture-28- Introduction to Biomaterials
    Dr. Kantesh Balani, Dr. Birkamjit Basu

    This module focuses on important biometallic alloys used in biomaterials, including titanium-based alloys, stainless steels, and Co-Cr-Mo alloys. Topics covered include:

    • Properties and applications of Ti-based alloys
    • Characteristics of stainless steels in biomedical applications
    • Overview of Co-Cr-Mo alloys and their uses

    Students will learn about the selection criteria for these materials in medical devices and implants.

  • Mod-01 Lec-29 Lecture-29-Introduction to Biomaterials
    Dr. Kantesh Balani, Dr. Birkamjit Basu

    This module introduces the fundamental concepts of Materials Science, focusing on the properties that define various material classes. Students will explore the critical attributes that biomaterials must possess to ensure effective application within the biological context.

    Key topics include:

    • Basic principles of Materials Science
    • Comparative analysis of important material classes
    • Defining property requirements for biomaterials
    • Understanding biocompatibility
  • Mod-01 Lec-30 Lecture-30- Introduction to Biomaterials
    Dr. Kantesh Balani, Dr. Birkamjit Basu

    This module delves into the specific property requirements of biomaterials, emphasizing their importance in medical applications. Students will gain insights into the concept of biocompatibility and how it affects material selection for various biomedical devices.

    Topics covered include:

    • Definition and importance of biocompatibility
    • Criteria for selecting biomaterials
    • Impact of material properties on biological response
  • Mod-01 Lec-31 Lecture-31- Introduction to Biomaterials
    Dr. Kantesh Balani, Dr. Birkamjit Basu

    This module provides an overview of the structure and properties of biological cells and tissues. It emphasizes the interaction between biomaterials and biological systems, allowing students to understand how these interactions influence material performance.

    Key learning points include:

    • Cell structure and function
    • Tissue organization and properties
    • Interaction mechanisms between cells and materials
  • Mod-01 Lec-32 Lecture-32-Introduction to Biomaterials
    Dr. Kantesh Balani, Dr. Birkamjit Basu

    This module focuses on the critical aspects of cell-material interactions, including how foreign bodies are recognized by the immune system. Students will examine the foreign body response and its implications for the design of biomaterials.

    Topics include:

    • Cell-material interaction mechanisms
    • Foreign body response details
    • Impacts on biomaterial functionality
  • Mod-01 Lec-33 Lecture-33- Introduction to Biomaterials
    Dr. Kantesh Balani, Dr. Birkamjit Basu

    This module covers various methods for assessing the biocompatibility of biomaterials. Students will learn about different in vitro biochemical assays that evaluate cellular responses to biomaterials, providing insights into their compatibility.

    Key assessment techniques include:

    1. Cellular adhesion assays
    2. Cellular viability assessments using MTT
    3. Osteogenic differentiation assays using ALP
    4. Biomineralization assays using Osteocalcin
  • Mod-01 Lec-34 Lecture-34- Introduction to Biomaterials
    Dr. Kantesh Balani, Dr. Birkamjit Basu

    This module examines in vivo testing methods and histocompatibility assessment, focusing on the biological response to implanted biomaterials. Students will learn about the importance of these tests for ensuring safety and effectiveness in biomedical applications.

    Key topics include:

    • Overview of in vivo testing procedures
    • Histocompatibility and its significance
    • Regulatory considerations for testing
  • Mod-01 Lec-35 Lecture-35- Introduction to Biomaterials
    Dr. Kantesh Balani, Dr. Birkamjit Basu

    This module addresses the assessment of genotoxicity concerning biomaterials, focusing on the potential physical damage to DNA caused by material eluates. Students will explore methods for evaluating the safety of biomaterials in terms of genetic integrity.

    Topics covered include:

    • Definition and importance of genotoxicity
    • Evaluation methods for assessing DNA damage
    • Implications for biomaterial safety
  • Mod-01 Lec-36 Lecture-36-Introduction to Biomaterials
    Dr. Kantesh Balani, Dr. Birkamjit Basu

    This module delves into the essential concepts of biomaterials, beginning with the foundations of Materials Science. Students will explore:

    • Fundamental properties of various material classes.
    • Requirements for biomaterials, focusing on biocompatibility.
    • The structural and functional aspects of biological cells and tissues.

    Understanding how these components interact with materials is crucial, particularly in the context of foreign body responses and cellular interactions.

  • Mod-01 Lec-37 Lecture-37-Introduction to Biomaterials
    Dr. Kantesh Balani, Dr. Birkamjit Basu

    This module focuses on the assessment of biocompatibility of biomaterials through various in vitro biochemical assays. Key topics include:

    1. Cellular adhesion techniques.
    2. Cellular viability tests using MTT assays.
    3. Osteogenic differentiation evaluated through ALP assays.
    4. Biomineralization assessment via Osteocalcin assays.

    Students will gain hands-on experience in these methodologies to evaluate the compatibility of materials intended for biological use.

  • Mod-01 Lec-38 Lecture-38-Introduction to Biomaterials
    Dr. Kantesh Balani, Dr. Birkamjit Basu

    This module covers in vivo testing methods and histocompatibility assessments for biomaterials. It includes:

    • In vivo testing procedures and their significance.
    • Evaluation of histocompatibility to determine the interaction between biomaterials and living tissues.
    • Genotoxicity assessments to analyze potential DNA damage caused by biomaterial eluates.

    Students will explore these critical assessments to ensure the safety and effectiveness of biomaterials in medical applications.

  • Mod-01 Lec-39 Lecture-39-Introduction to Biomaterials
    Dr. Kantesh Balani, Dr. Birkamjit Basu

    This module introduces important biometallic alloys such as Ti-based alloys, stainless steels, and Co-Cr-Mo alloys. It encompasses:

    • The properties and applications of bioinert, bioactive, and bioresorbable ceramics.
    • Processing techniques for various bioceramic materials, particularly hydroxyapatite.
    • Synthesis methods for biocompatible coatings on implant materials.
    • Innovative techniques like plasma spraying of carbon nanotube reinforced hydroxyapatite.
    • Exploration of biodegradable polymers and their relevance in bio-implant applications.

    The module will also cover design concepts for developing new materials specifically aimed at bio-implant applications.