This module focuses on human gene therapy, discussing its principles, methods, and potential applications in treating genetic disorders.
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This module introduces eukaryotic RNA polymerases and the fundamental transcription factors required for initiating gene transcription. It discusses the structure and function of various polymerases, including RNA Pol I, II, and III, and their roles in synthesizing different RNA types.
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This module focuses on the diversity of core promoter elements in eukaryotic gene expression. It explores how different promoter sequences influence the binding of transcription machinery and the initiation of transcription.
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This module delves into the diversity of general transcription factors essential for eukaryotic gene expression. It covers the various transcription factors, their roles, and how they interact with RNA polymerases to facilitate transcription.
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This module examines proximal and distal promoter elements, enhancers, silencers, and gene-specific regulators. Understanding their functions is essential for grasping how eukaryotic gene expression is fine-tuned.
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This module focuses on transcription factors' DNA binding domains, essential for recognizing and interacting with specific DNA sequences. The structure and function of these domains are crucial for understanding gene regulation.
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This module addresses transcription factors' transcription activation domains, which are vital for recruiting the transcriptional machinery necessary for gene expression.
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This module investigates the role of chromatin in eukaryotic gene regulation. It explains how chromatin structure affects gene accessibility and transcriptional activity.
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This module focuses on the role of histones in eukaryotic gene regulation. It discusses how histone modifications can influence gene expression by altering chromatin structure.
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This module discusses the role of DNA methylation in eukaryotic gene regulation. It highlights how methylation patterns can influence gene expression and contribute to cellular differentiation.
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This module examines chromatin remodeling and its implications for gene regulation. It discusses various chromatin remodeling complexes that alter chromatin structure to facilitate transcription.
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This module focuses on the co-transcriptional and post-transcriptional modifications of pre-messenger RNA. It discusses how these modifications are critical for mRNA stability and translation.
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This module examines additional co-transcriptional and post-transcriptional modifications of pre-messenger RNA, focusing on the specific roles of RNA polymerase II in processing.
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This module focuses on the regulation of RNA Pol I transcription. It discusses how this polymerase is responsible for synthesizing ribosomal RNA (rRNA) and the factors that influence its activity.
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This module examines the regulation of tRNA and 5S rRNA synthesis by RNA Polymerase III. It highlights the significance of these RNA types in protein synthesis and cellular function.
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This module introduces signal transduction pathways, providing an overview of how extracellular signals are transmitted into cellular responses, leading to changes in gene expression.
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This module focuses on the regulation of gene expression by cyclic AMP (cAMP). It details how cAMP acts as a secondary messenger in signaling pathways that influence transcription.
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This module discusses the regulation of gene expression by secondary messengers other than cAMP. It examines various signaling molecules and their roles in transcriptional regulation.
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This module focuses on the regulation of gene expression by Protein Kinase C (PKC). It discusses how PKC functions in various signaling pathways to modulate transcriptional activity.
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This module examines the regulation of gene expression by growth factors. It explains how these signaling molecules influence cellular processes, including transcriptional regulation.
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This module focuses on the regulation of gene expression by cytokines. It discusses how these immune signaling molecules affect transcription and cellular responses.
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This module examines the regulation of gene expression by steroid hormones. It highlights the mechanisms by which these hormones influence transcriptional activity through intracellular receptors.
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This module discusses the regulation of gene expression by type II nuclear receptors. It explains how these receptors function as transcription factors in response to steroid hormones and other ligands.
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This module focuses on the mechanism of transcriptional activation by nuclear receptors. It details how these receptors influence gene expression upon binding their ligands.
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This module discusses gene regulation during Drosophila development, highlighting the mechanisms that control gene expression at various developmental stages.
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This module examines the signal transduction pathways involved in embryonic development, focusing on how these pathways regulate gene expression during early development.
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This module focuses on homeotic genes and their role in determining body plan and segment identity during development. It discusses how these genes are regulated.
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This module discusses the epigenetic regulation of gene expression during development, focusing on how epigenetic modifications influence transcriptional activity.
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This module focuses on embryonic stem cells and their potential for transcription factor-mediated epigenetic reprogramming. It discusses how these cells can differentiate into various cell types.
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This module discusses cloning and expression vectors, focusing on their design and application in molecular biology for gene cloning and protein expression.
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This module focuses on eukaryotic protein expression systems, detailing different systems used to produce proteins in eukaryotic cells.
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This module continues the discussion on eukaryotic protein expression systems, examining specific strategies for optimizing protein production in these systems.
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This module examines advanced eukaryotic protein expression systems, including the use of mammalian cells and viral vectors for gene expression.
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This module focuses on human gene therapy, discussing its principles, methods, and potential applications in treating genetic disorders.
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This module discusses DNA vaccines, explaining their mechanism of action and potential as a novel approach in preventive medicine and immunotherapy.
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This module focuses on transgenic animals and their significance in research and biotechnology, discussing methods for creating and utilizing these organisms.
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This module discusses transgenic plants, focusing on the methods used to create these organisms and their applications in agriculture and environmental science.
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This module focuses on knockout mice, discussing how these genetically modified organisms are created and their applications in studying gene function.
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This module discusses the regulation of eukaryotic gene expression by small RNAs, particularly RNA interference (RNAi). It covers the mechanisms by which small RNAs influence gene regulation.
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This module focuses on genomics and proteomics, discussing how high-throughput techniques are used to study gene expression and protein function on a large scale.
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This module discusses metabolic engineering and synthetic biology, focusing on how these fields are applied to modify and design biological systems for various applications.
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